Akhilesh Vats, ACME Research Solutions
Unveil Article Specifications
Author: Akhilesh Vats
Journal: PEXACY International Journal of Pharmaceutical Science
Volume/Issue: Volume 2, Issue 3
Page Range: 14-29
Publication Date: 02/03/2023
Contact: Akhileshvats@acmereserchlabs.in
Abstract- This study aimed to formulate an Herbal Nanogel from Terminalia arjuna bark for anti-inflammatory activity and assess its performance using in vitro parameters. Terminalia arjuna has long been used in Ayurvedic medicine due to its potent anti-inflammatory effects. In this study, the bark of Terminalia arjuna was collected, dried, and extracted with a solvent. The extract was then formulated into a Nanogel. Dynamic light scattering was used to measure the size of Nanogel particles, and transmission electron microscopy revealed their morphology as spherical in shape. Zeta potential measurements also confirmed good stability for this material: a negative surface charge indicated good stability. In vitro anti-inflammatory activity of the Nanogel was assessed using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The Nanogel was evaluated for its ability to inhibit production of nitric oxide (NO), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Results revealed that at 100 mg/mL concentrations, there was significant inhibition in NO, IL-6 and TNF-α – with maximum inhibition observed at 200 μg/mL concentration.
Author- Akhilesh Vats, ACME Research Solutions
Keywords: Nanogel, Terminalia arjuna, Anti-inflammatory Nanogel
Article can be accessed online on: PEXACY International Journal of Pharmaceutical Science
DOI: 10.5281/zenodo.7693001
*Corresponding Author- info@acmeresearchlabs.in
Update: Received on 04/02/2023; Accepted; 18/02/2023, Published on; 02/03/2023